State‐Dependent Drug Interactions with Ion Channels
Stefan I. McDonough, Bruce P. Bean · Methods and principles in medicinal chemistry · 2006
This chapter contains sections titled: Introduction Ion Channels as Drug Receptors Ion Channels Adopt Multiple Conformations Biophysics Meets Pharmacology: State Dependence, Voltage Dependence, and the Modulated Receptor Model Use Dependence Physical Meaning of State Dependence State Dependence in Drug Discovery Future Directions for Ion Channel Drug Discovery