Tight Binding Inhibition
Robert A. Copeland · 2013
This chapter contains sections titled: Key Learning Points Effects of Tight Binding Inhibition on Concentration–Response Data The IC50 Value Depends on Kiapp and [E]T Morrison's Quadratic Equation for Fitting Concentration–Response Data for Tight Binding Inhibitors Determining Modality for Tight Binding Enzyme Inhibitors Tight Binding Inhibitors Often Display Slow Binding Behavior Practical Approaches to Overcoming the Tight Binding Limit in Determining Ki Enzyme-Reaction Intermediate Analogues as Examples of Tight Binding Inhibitors Potential Clinical Advantages of Tight Binding Inhibitors Determination of [E]T Using Tight Binding Inhibitors Summary References