Multipoint mapping calculations for sperm-typing data.
Laura C. Lazzeroni, Norman Arnheim, Karin Schmitt, Kenneth L. Lange · PubMed · 1994
This paper explains how multipoint likelihoods can be computed for sperm-typing data. Experimental errors such as multiple sperm per tube, inadequate amplification, and contamination by exogenous DNA are explicitly taken into account. By limiting the number of sperm theoretically possible per tube to a predetermined maximum and by assuming no chiasma interference, maximum-likelihood estimation can be carried out rapidly using the theory of hidden Markov chains.