Toxicogenomics: Applications in In Vitro Systems
Dimitri Semizarov, Eric A.G. Blomme · 2008
This chapter contains sections titled: Introductory Remarks on In Vitro Toxicology Overview of Current Approaches to In Vitro Toxicology Toxicogenomics in In Vitro Systems: Technical Considerations Proof-of-Concept Studies using Primary Rat Hepatocytes Use of Gene Expression Profiling to Assess Genotoxicity Application of Gene Expression Profiling for In Vitro Detection of Phospholipidosis Toxicogenomics in Assessment of Idiosyncratic Hepatotoxicity Do Peripheral Blood Mononuclear Cells Represent a Useful Alternative In Vitro Model? Current and Future Use of In Vitro Toxicogenomics Conclusions References