Lipitor® (Atorvastatin Calcium)
Peter J. Harrington · 2010
This chapter contains sections titled: Lipitor®, Heart Disease, and Stroke Pyrrole Formation by [3 + 2]-cycloaddition 1,4-diketones for Paal–Knorr Pyrrole Synthesis Primary Amines for Paal–Knorr Pyrrole Synthesis Paal–Knorr Pyrrole Synthesis Pyrrole 117 from 1,4-diketone 21 and ethyl 2-((4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (116) Side Chain Elaboration after Pyrrole Ring Construction Atorvastatin (1) Calcium Amorphous Atorvastatin Calcium from Atorvastatin Calcium The Continuing Refinement of Analytical Methods: Identifying Process Impurities and Evaluating Drug Product Stability During Storage and Formulation The Best Process Available Alternative Approaches to tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (8) Structures Searched References