Case Studies on Eliminating/Reducing Reactive Metabolite Formation in Drug Discovery
Amit S.S. Kalgutkar, Deepak Dalvie, Ronald Scott Obach, Dennis A. Smith · Methods and principles in medicinal chemistry · 2012
This chapter contains sections titled: Abbreviations Medicinal Chemistry Tactics to Eliminate Reactive Metabolite Formation Eliminating Reactive Metabolite Formation on Heterocyclic Ring Systems Medicinal Chemistry Strategies to Mitigate Bioactivation of Electron-Rich Aromatic Rings Medicinal Chemistry Strategies to Mitigate Bioactivation on a Piperazine Ring System 4-Fluorofelbamate as a Potentially Safer Alternative to Felbamate Concluding Remarks References