Protein regulation, protein-protein interactions and structural genomics
Boštjan Kobe · 2002
This paper is based on a lecture presented at the 1stCentral European Conference “Chemistry towards Biology ” held at Portorož, Slovenia during September 812th, 2002. Received 18122002 The new technical developments and the success of genome sequencing projects have prompted a new approach to scientific investigation and discovery in every field of biochemistry and molecular biology, including structural biology. One of the most prominent recent developments is the birth of structural genomics, a worldwide initiative that aims to provide the threedimensional structures of all representative proteins. However, structural biology faces an exciting future beyond structural genomics ; if we are to understand how the proteome works and use the genomic information for therapeutic purposes, studies of proteinprotein interactions and macromolecular complexes, mechanism and regulation of macromolecular function, membrane protein structure, and structurebased therapeutic design must be pursued in parallel. Successful approaches will combine large scale, highthroughput approaches developed through structural genomics with more