Analogues as a Means of Discovering New Drugs
Camille Georges Wermuth · 2006
This chapter contains sections titled: Designing of Analogues Analogues Produced by Homologous Variations Homology Through Monoalkylation Polymethylenic Bis-Ammonium Compounds: Hexa- and Decamethonium Homology in Cyclic Compounds Analogues Produced by Vinylogy Zaprinast Benzologues Analogues Produced by Isosteric Variations The Dominant Parameter is Structural The Dominant Parameter is Electronic The Dominant Parameter is Lipophilicity Positional Isomers Produced as Analogues Optical Isomers Produced as Analogues Racemic Switches Specific Profile for Each Enantiomer Analogues Produced by Ring Transformations Twin Drugs The Pros and Cons of Analogue Design The Success is Almost Warranted The Information is Available Financial Considerations Emergence of New Properties Analogue Design as a Means of Discovering New Drugs New Uses for Old Drugs The PASS Program New Leads from Old Drugs: The SOSA Approach Definition Rationale Availability Examples Discussion Conclusion